Journal: Diagnostic Microbiology and Infectious Disease

Article Title: Enhanced Detection of Community-Acquired Pneumonia Pathogens With the BioFire® Pneumonia FilmArray® Panel

doi: 10.1016/j.diagmicrobio.2020.115246

Figure Lengend Snippet: Components of Multi-Test Bundle and BioFire® Pneumonia FilmArray® Testing

Article Snippet: The Biofire® Pneumonia FilmArray® (BPFA) panel probes sputum samples for 8 respiratory viruses and 18 bacteria with a 1 to 2-hour TAT.

Techniques:

Journal: Diagnostic Microbiology and Infectious Disease

Article Title: Enhanced Detection of Community-Acquired Pneumonia Pathogens With the BioFire® Pneumonia FilmArray® Panel

doi: 10.1016/j.diagmicrobio.2020.115246

Figure Lengend Snippet: Comparison of organism targets in the Biofire® Respiratory FilmArray and the Biofire Pneumonia FilmArray® Panels. The Respiratory Panel requires a nasopharyngeal swab and the Pneumonia Panel requires sputum * .

Article Snippet: The Biofire® Pneumonia FilmArray® (BPFA) panel probes sputum samples for 8 respiratory viruses and 18 bacteria with a 1 to 2-hour TAT.

Techniques: Comparison, Bacteria, Virus

Journal: Diagnostic Microbiology and Infectious Disease

Article Title: Enhanced Detection of Community-Acquired Pneumonia Pathogens With the BioFire® Pneumonia FilmArray® Panel

doi: 10.1016/j.diagmicrobio.2020.115246

Figure Lengend Snippet: Clinical Classification of Patients Based on Integration of Test Results with Clinical Judgment

Article Snippet: The Biofire® Pneumonia FilmArray® (BPFA) panel probes sputum samples for 8 respiratory viruses and 18 bacteria with a 1 to 2-hour TAT.

Techniques: Imaging, Biomarker Discovery, Virus

Journal: Diagnostic Microbiology and Infectious Disease

Article Title: Enhanced Detection of Community-Acquired Pneumonia Pathogens With the BioFire® Pneumonia FilmArray® Panel

doi: 10.1016/j.diagmicrobio.2020.115246

Figure Lengend Snippet: Number of patients with bacterial, viral, or any (bacterial and/or viral) potential pathogens detected by MTB and BPFA

Article Snippet: The Biofire® Pneumonia FilmArray® (BPFA) panel probes sputum samples for 8 respiratory viruses and 18 bacteria with a 1 to 2-hour TAT.

Techniques: Bacteria, Virus

Journal: Diagnostic Microbiology and Infectious Disease

Article Title: Enhanced Detection of Community-Acquired Pneumonia Pathogens With the BioFire® Pneumonia FilmArray® Panel

doi: 10.1016/j.diagmicrobio.2020.115246

Figure Lengend Snippet: Comparison of MTB versus BPFA for detecting number of patients with potential bacterial pathogens, with or without detectable virus. Some patients were detected with more than one bacterial species.

Article Snippet: The Biofire® Pneumonia FilmArray® (BPFA) panel probes sputum samples for 8 respiratory viruses and 18 bacteria with a 1 to 2-hour TAT.

Techniques: Comparison, Virus

Journal: Diagnostic Microbiology and Infectious Disease

Article Title: Enhanced Detection of Community-Acquired Pneumonia Pathogens With the BioFire® Pneumonia FilmArray® Panel

doi: 10.1016/j.diagmicrobio.2020.115246

Figure Lengend Snippet: Comparison of number of patients detected with Streptococcus pneumoniae by individual elements of the multi-test bundle vs the BioFire® Pneumonia FilmArray®. Some patients had more than one test element positive for S. pneumoniae . PCR denotes polymerase chain reaction.

Article Snippet: The Biofire® Pneumonia FilmArray® (BPFA) panel probes sputum samples for 8 respiratory viruses and 18 bacteria with a 1 to 2-hour TAT.

Techniques: Comparison, Polymerase Chain Reaction

Journal: Diagnostic Microbiology and Infectious Disease

Article Title: Enhanced Detection of Community-Acquired Pneumonia Pathogens With the BioFire® Pneumonia FilmArray® Panel

doi: 10.1016/j.diagmicrobio.2020.115246

Figure Lengend Snippet: Comparison of MTB versus BPFA for detecting number of patients with potential viral pathogens, with or without detectable bacteria Some patients were detected with more than one viral species.

Article Snippet: The Biofire® Pneumonia FilmArray® (BPFA) panel probes sputum samples for 8 respiratory viruses and 18 bacteria with a 1 to 2-hour TAT.

Techniques: Comparison, Bacteria

Journal: Diagnostic Microbiology and Infectious Disease

Article Title: Enhanced Detection of Community-Acquired Pneumonia Pathogens With the BioFire® Pneumonia FilmArray® Panel

doi: 10.1016/j.diagmicrobio.2020.115246

Figure Lengend Snippet: Comparative detection of multiple bacterial and viral species with BPFA versus MTB

Article Snippet: The Biofire® Pneumonia FilmArray® (BPFA) panel probes sputum samples for 8 respiratory viruses and 18 bacteria with a 1 to 2-hour TAT.

Techniques: Virus, Bacteria

Journal: Diagnostic Microbiology and Infectious Disease

Article Title: Enhanced Detection of Community-Acquired Pneumonia Pathogens With the BioFire® Pneumonia FilmArray® Panel

doi: 10.1016/j.diagmicrobio.2020.115246

Figure Lengend Snippet: Comparative laboratory cost of MTB vs projected cost of BPFA bundle

Article Snippet: The Biofire® Pneumonia FilmArray® (BPFA) panel probes sputum samples for 8 respiratory viruses and 18 bacteria with a 1 to 2-hour TAT.

Techniques:

Journal: BMJ Open

Article Title: Combined use of a broad-panel respiratory multiplex PCR and procalcitonin to reduce duration of antibiotics exposure in patients with severe community-acquired pneumonia (MULTI-CAP): a multicentre, parallel-group, open-label, individual randomised trial conducted in French intensive care units

doi: 10.1136/bmjopen-2020-048187

Figure Lengend Snippet: Trial design. In the intervention arm, before the end of day 1, clinicians have to consider all the early microbiological results (mPCR FA-PPP, urine antigen assays, blood cultures and Gram stain examination of respiratory tract sample) and procalcitonin before the end of day 1, and subsequently to apply an algorithm of early antibiotics discontinuation or de-escalation (red square). This algorithm is described in . In both arms, at day 3 and day after day until day 7, clinicians are encouraged to consider antibiotic discontinuation, based on procalcitonin values and kinetics. CAP, community-acquired pneumonia; FA-PPP, FilmArray Pneumonia Panel Plus; ICU, intensive care unit; mPCR, multiplex PCR.

Article Snippet: In the experimental strategy arm, the microbiological diagnosis combines a broad-panel respiratory mPCR (FilmArray Pneumonia Panel Plus (FA-PPP), BioFire Biomérieux) with conventional microbiological investigations.

Techniques: Staining, Multiplex Assay

Journal: BMJ Open

Article Title: Combined use of a broad-panel respiratory multiplex PCR and procalcitonin to reduce duration of antibiotics exposure in patients with severe community-acquired pneumonia (MULTI-CAP): a multicentre, parallel-group, open-label, individual randomised trial conducted in French intensive care units

doi: 10.1136/bmjopen-2020-048187

Figure Lengend Snippet: Algorithm of early antibiotics de-escalation or discontinuation. The algorithm is applied in the intervention arm only (see red square, ). mPCR, multiplex PCR; ICU, intensive care unit; PCT, procalcitonin.

Article Snippet: In the experimental strategy arm, the microbiological diagnosis combines a broad-panel respiratory mPCR (FilmArray Pneumonia Panel Plus (FA-PPP), BioFire Biomérieux) with conventional microbiological investigations.

Techniques: Multiplex Assay

Journal: BMJ Open

Article Title: Combined use of a broad-panel respiratory multiplex PCR and procalcitonin to reduce duration of antibiotics exposure in patients with severe community-acquired pneumonia (MULTI-CAP): a multicentre, parallel-group, open-label, individual randomised trial conducted in French intensive care units

doi: 10.1136/bmjopen-2020-048187

Figure Lengend Snippet: Primary and secondary outcomes

Article Snippet: In the experimental strategy arm, the microbiological diagnosis combines a broad-panel respiratory mPCR (FilmArray Pneumonia Panel Plus (FA-PPP), BioFire Biomérieux) with conventional microbiological investigations.

Techniques: Bacteria, Biomarker Discovery